Below is a possible solution to the challenge - Challenge 48 - Whether a Sentence is Pangram or Not

=IF(ISNUMBER(SUMPRODUCT(MATCH(ROW($65:$90),INDEX(CODE(MID(SUBSTITUTE(SUBSTITUTE(
SUBSTITUTE(UPPER(A1)," ",""),".",""),",",""),ROW(INDIRECT("1:"&LEN(SUBSTITUTE(SUBSTITUTE(
SUBSTITUTE(A1," ",""),".",""),",","")))),1)),,),0))),"Pangram","Not Pangram")